Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
Identifieur interne : 000094 ( Main/Exploration ); précédent : 000093; suivant : 000095Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
Auteurs : Franziska Herster [Allemagne] ; Zsofia Bittner [Allemagne] ; Nathan K. Archer [États-Unis] ; Sabine Dickhöfer [Allemagne] ; David Eisel [Allemagne] ; Tatjana Eigenbrod [Allemagne] ; Thomas Knorpp [Allemagne] ; Nicole Schneiderhan-Marra [Allemagne] ; Markus W. Löffler [Allemagne] ; Hubert Kalbacher [Allemagne] ; Tim Vierbuchen [Allemagne] ; Holger Heine [Allemagne] ; Lloyd S. Miller [États-Unis] ; Dominik Hartl [Allemagne, Suisse] ; Lukas Freund [Allemagne] ; Knut Sch Kel [Allemagne] ; Martin Heister [Allemagne] ; Kamran Ghoreschi [Allemagne] ; Alexander N. R. Weber [Allemagne]Source :
- Nature Communications [ 2041-1723 ] ; 2020.
Abstract
Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration and high levels of the antimicrobial peptide, LL37. LL37 in complex with DNA and RNA is thought to initiate disease exacerbation via plasmacytoid dendritic cells. However, the source of nucleic acids supposed to start this initial inflammatory event remains unknown. We show here that primary murine and human PMNs mount a fulminant and self-propagating neutrophil extracellular trap (NET) and cytokine response, but independently of the canonical NET component, DNA. Unexpectedly, RNA, which is abundant in NETs and psoriatic but not healthy skin, in complex with LL37 triggered TLR8/TLR13-mediated cytokine and NET release by PMNs in vitro and in vivo. Transfer of NETs to naive human PMNs prompts additional NET release, promoting further inflammation. Our study thus uncovers a self-propagating vicious cycle contributing to chronic inflammation in psoriasis, and NET-associated RNA (naRNA) as a physiologically relevant NET component.
Url:
DOI: 10.1038/s41467-019-13756-4
PubMed: 31913271
PubMed Central: 6949246
Affiliations:
- Allemagne, Suisse, États-Unis
- Bade-Wurtemberg, Berlin, District de Karlsruhe, District de Tübingen, Maryland, Rhénanie-Palatinat
- Berlin, Heidelberg, Mayence, Tübingen
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000152
- to stream Pmc, to step Curation: 000152
- to stream Pmc, to step Checkpoint: 000087
- to stream Ncbi, to step Merge: 000E15
- to stream Ncbi, to step Curation: 000E15
- to stream Ncbi, to step Checkpoint: 000E15
- to stream Main, to step Merge: 000094
- to stream Main, to step Curation: 000094
Le document en format XML
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Archer</name><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id><institution-id institution-id-type="GRID">grid.21107.35</institution-id><institution>Department of Dermatology,</institution><institution>Johns Hopkins University School of Medicine,</institution></institution-wrap>Baltimore, MD 21231 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Dickhofer, Sabine" sort="Dickhofer, Sabine" uniqKey="Dickhofer S" first="Sabine" last="Dickhöfer">Sabine Dickhöfer</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id><institution-id institution-id-type="GRID">grid.10392.39</institution-id><institution>Department of Immunology,</institution><institution>University of Tübingen,</institution></institution-wrap>Auf der Morgenstelle 15, 72076 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Auf der Morgenstelle 15, 72076 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Eisel, David" sort="Eisel, David" uniqKey="Eisel D" first="David" last="Eisel">David Eisel</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id><institution-id institution-id-type="GRID">grid.10392.39</institution-id><institution>Department of Immunology,</institution><institution>University of Tübingen,</institution></institution-wrap>Auf der Morgenstelle 15, 72076 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Auf der Morgenstelle 15, 72076 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 4692 2203</institution-id><institution-id institution-id-type="GRID">grid.434484.b</institution-id><institution>Present Address: David Eisel, BioNTech,</institution></institution-wrap>An der Goldgrube 12, 55131 Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>An der Goldgrube 12, 55131 Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Eigenbrod, Tatjana" 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Knorpp</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9457 1306</institution-id><institution-id institution-id-type="GRID">grid.461765.7</institution-id><institution>NMI Natural and Medical Sciences Institute at the University of Tübingen,</institution></institution-wrap>Markwiesenstr. 55, 72770 Reutlingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Markwiesenstr. 55, 72770 Reutlingen</wicri:regionArea><wicri:noRegion>72770 Reutlingen</wicri:noRegion><wicri:noRegion>72770 Reutlingen</wicri:noRegion><wicri:noRegion>72770 Reutlingen</wicri:noRegion></affiliation></author><author><name sortKey="Schneiderhan Marra, Nicole" sort="Schneiderhan Marra, Nicole" uniqKey="Schneiderhan Marra N" first="Nicole" last="Schneiderhan-Marra">Nicole Schneiderhan-Marra</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9457 1306</institution-id><institution-id institution-id-type="GRID">grid.461765.7</institution-id><institution>NMI Natural and Medical Sciences Institute at the University of Tübingen,</institution></institution-wrap>Markwiesenstr. 55, 72770 Reutlingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Markwiesenstr. 55, 72770 Reutlingen</wicri:regionArea><wicri:noRegion>72770 Reutlingen</wicri:noRegion><wicri:noRegion>72770 Reutlingen</wicri:noRegion><wicri:noRegion>72770 Reutlingen</wicri:noRegion></affiliation></author><author><name sortKey="Loffler, Markus W" sort="Loffler, Markus W" uniqKey="Loffler M" first="Markus W." last="Löffler">Markus W. Löffler</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id><institution-id institution-id-type="GRID">grid.10392.39</institution-id><institution>Department of Immunology,</institution><institution>University of Tübingen,</institution></institution-wrap>Auf der Morgenstelle 15, 72076 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Auf der Morgenstelle 15, 72076 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0196 8249</institution-id><institution-id institution-id-type="GRID">grid.411544.1</institution-id><institution>Department of General, Visceral and Transplant Surgery,</institution><institution>University Hospital Tübingen,</institution></institution-wrap>Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hoppe-Seyler-Str. 3, 72076 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0196 8249</institution-id><institution-id institution-id-type="GRID">grid.411544.1</institution-id><institution>Department of Clinical Pharmacology,</institution><institution>University Hospital Tübingen,</institution></institution-wrap>Auf der Morgenstelle 8, 72076 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Auf der Morgenstelle 8, 72076 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Kalbacher, Hubert" sort="Kalbacher, Hubert" uniqKey="Kalbacher H" first="Hubert" last="Kalbacher">Hubert Kalbacher</name><affiliation wicri:level="3"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id><institution-id institution-id-type="GRID">grid.10392.39</institution-id><institution>Interfaculty Institute of Biochemistry, University of Tübingen,</institution></institution-wrap>Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hoppe-Seyler-Str. 4, 72076 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Vierbuchen, Tim" sort="Vierbuchen, Tim" uniqKey="Vierbuchen T" first="Tim" last="Vierbuchen">Tim Vierbuchen</name><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0493 9170</institution-id><institution-id institution-id-type="GRID">grid.418187.3</institution-id><institution>Research Group Innate Immunity, Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), Deutsches Zentrum für Lungenforschung (DZL),</institution></institution-wrap>Parkallee 22, 23845 Borstel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Parkallee 22, 23845 Borstel</wicri:regionArea><wicri:noRegion>23845 Borstel</wicri:noRegion><wicri:noRegion>23845 Borstel</wicri:noRegion><wicri:noRegion>23845 Borstel</wicri:noRegion></affiliation></author><author><name sortKey="Heine, Holger" sort="Heine, Holger" uniqKey="Heine H" first="Holger" last="Heine">Holger Heine</name><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0493 9170</institution-id><institution-id institution-id-type="GRID">grid.418187.3</institution-id><institution>Research Group Innate Immunity, Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), Deutsches Zentrum für Lungenforschung (DZL),</institution></institution-wrap>Parkallee 22, 23845 Borstel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Parkallee 22, 23845 Borstel</wicri:regionArea><wicri:noRegion>23845 Borstel</wicri:noRegion><wicri:noRegion>23845 Borstel</wicri:noRegion><wicri:noRegion>23845 Borstel</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Lloyd S" sort="Miller, Lloyd S" uniqKey="Miller L" first="Lloyd S." last="Miller">Lloyd S. Miller</name><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 9311</institution-id><institution-id institution-id-type="GRID">grid.21107.35</institution-id><institution>Department of Dermatology,</institution><institution>Johns Hopkins University School of Medicine,</institution></institution-wrap>Baltimore, MD 21231 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Hartl, Dominik" sort="Hartl, Dominik" uniqKey="Hartl D" first="Dominik" last="Hartl">Dominik Hartl</name><affiliation wicri:level="3"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id><institution-id institution-id-type="GRID">grid.10392.39</institution-id><institution>University Children’s Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen,</institution></institution-wrap>Hoppe-Seyler-Str. 1, 72076 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hoppe-Seyler-Str. 1, 72076 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1515 9979</institution-id><institution-id institution-id-type="GRID">grid.419481.1</institution-id><institution>Novartis Institutes for BioMedical Research (NIBR),</institution></institution-wrap>Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Basel</wicri:regionArea></affiliation></author><author><name sortKey="Freund, Lukas" sort="Freund, Lukas" uniqKey="Freund L" first="Lukas" last="Freund">Lukas Freund</name><affiliation wicri:level="3"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0328 4908</institution-id><institution-id institution-id-type="GRID">grid.5253.1</institution-id><institution>Department of Dermatology,</institution><institution>University Hospital Heidelberg,</institution></institution-wrap>Im Neuenheimer Feld 440, 69120 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Im Neuenheimer Feld 440, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Sch Kel, Knut" sort="Sch Kel, Knut" uniqKey="Sch Kel K" first="Knut" last="Sch Kel">Knut Sch Kel</name><affiliation wicri:level="3"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0328 4908</institution-id><institution-id institution-id-type="GRID">grid.5253.1</institution-id><institution>Department of Dermatology,</institution><institution>University Hospital Heidelberg,</institution></institution-wrap>Im Neuenheimer Feld 440, 69120 Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Im Neuenheimer Feld 440, 69120 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Heister, Martin" sort="Heister, Martin" uniqKey="Heister M" first="Martin" last="Heister">Martin Heister</name><affiliation wicri:level="3"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0196 8249</institution-id><institution-id institution-id-type="GRID">grid.411544.1</institution-id><institution>Department of Dermatology,</institution><institution>University Hospital Tübingen,</institution></institution-wrap>Liebermeisterstr. 25, 72076 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Liebermeisterstr. 25, 72076 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Ghoreschi, Kamran" sort="Ghoreschi, Kamran" uniqKey="Ghoreschi K" first="Kamran" last="Ghoreschi">Kamran Ghoreschi</name><affiliation wicri:level="3"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0196 8249</institution-id><institution-id institution-id-type="GRID">grid.411544.1</institution-id><institution>Department of Dermatology,</institution><institution>University Hospital Tübingen,</institution></institution-wrap>Liebermeisterstr. 25, 72076 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Liebermeisterstr. 25, 72076 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2218 4662</institution-id><institution-id institution-id-type="GRID">grid.6363.0</institution-id><institution>Department of Dermatology, Charité – Universitätsmedizin Berlin,</institution></institution-wrap>Charitéplatz 1, 10117 Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charitéplatz 1, 10117 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Weber, Alexander N R" sort="Weber, Alexander N R" uniqKey="Weber A" first="Alexander N. R." last="Weber">Alexander N. R. Weber</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2190 1447</institution-id><institution-id institution-id-type="GRID">grid.10392.39</institution-id><institution>Department of Immunology,</institution><institution>University of Tübingen,</institution></institution-wrap>Auf der Morgenstelle 15, 72076 Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Auf der Morgenstelle 15, 72076 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration and high levels of the antimicrobial peptide, LL37. LL37 in complex with DNA and RNA is thought to initiate disease exacerbation via plasmacytoid dendritic cells. However, the source of nucleic acids supposed to start this initial inflammatory event remains unknown. We show here that primary murine and human PMNs mount a fulminant and self-propagating neutrophil extracellular trap (NET) and cytokine response, but independently of the canonical NET component, DNA. Unexpectedly, RNA, which is abundant in NETs and psoriatic but not healthy skin, in complex with LL37 triggered TLR8/TLR13-mediated cytokine and NET release by PMNs in vitro and in vivo. Transfer of NETs to naive human PMNs prompts additional NET release, promoting further inflammation. Our study thus uncovers a self-propagating vicious cycle contributing to chronic inflammation in psoriasis, and NET-associated RNA (naRNA) as a physiologically relevant NET component.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Griffiths, Ce" uniqKey="Griffiths C">CE Griffiths</name></author><author><name sortKey="Barker, Jn" uniqKey="Barker J">JN Barker</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Sen, Bilge Bulbul" uniqKey="Sen B">Bilge Bulbul Sen</name></author><author><name sortKey="Rifaioglu, Emine Nur" uniqKey="Rifaioglu E">Emine Nur Rifaioglu</name></author><author><name sortKey="Ekiz, Ozlem" uniqKey="Ekiz O">Ozlem Ekiz</name></author><author><name sortKey="Inan, Mehmet Ugur" uniqKey="Inan M">Mehmet Ugur Inan</name></author><author><name sortKey="Sen, Tugba" uniqKey="Sen T">Tugba Sen</name></author><author><name sortKey="Sen, Nihat" uniqKey="Sen N">Nihat Sen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schon, Mp" uniqKey="Schon M">MP Schon</name></author><author><name sortKey="Broekaert, Sm" uniqKey="Broekaert S">SM Broekaert</name></author><author><name sortKey="Erpenbeck, L" uniqKey="Erpenbeck L">L Erpenbeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lande, R" uniqKey="Lande R">R Lande</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ganguly, D" uniqKey="Ganguly D">D Ganguly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brinkmann, V" uniqKey="Brinkmann V">V Brinkmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radic, M" uniqKey="Radic M">M Radic</name></author><author><name sortKey="Marion, Tn" uniqKey="Marion T">TN Marion</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sorensen, O" uniqKey="Sorensen O">O 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uniqKey="Yao Y">Y Yao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghoreschi, K" uniqKey="Ghoreschi K">K Ghoreschi</name></author><author><name sortKey="Weigert, C" uniqKey="Weigert C">C Weigert</name></author><author><name sortKey="Rocken, M" uniqKey="Rocken M">M Rocken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanel, Kh" uniqKey="Hanel K">KH Hanel</name></author><author><name sortKey="Cornelissen, C" uniqKey="Cornelissen C">C Cornelissen</name></author><author><name sortKey="Luscher, B" uniqKey="Luscher B">B Luscher</name></author><author><name sortKey="Baron, Jm" uniqKey="Baron J">JM Baron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schauber, J" uniqKey="Schauber J">J Schauber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morizane, S" uniqKey="Morizane S">S Morizane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Lj" uniqKey="Zhang L">LJ Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Behzad, Ar" uniqKey="Behzad A">AR Behzad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neumann, A" uniqKey="Neumann A">A Neumann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noll, F" uniqKey="Noll F">F Noll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gestermann, N" uniqKey="Gestermann N">N Gestermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warnatsch, A" uniqKey="Warnatsch A">A Warnatsch</name></author><author><name sortKey="Ioannou, M" uniqKey="Ioannou M">M Ioannou</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Papayannopoulos, V" uniqKey="Papayannopoulos V">V Papayannopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gregoire, M" uniqKey="Gregoire M">M Gregoire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tabeta, K" uniqKey="Tabeta K">K Tabeta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Xd" uniqKey="Li X">XD Li</name></author><author><name sortKey="Chen, Zj" uniqKey="Chen Z">ZJ Chen</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Faust, N" uniqKey="Faust N">N Faust</name></author><author><name sortKey="Varas, F" uniqKey="Varas F">F Varas</name></author><author><name sortKey="Kelly, Lm" uniqKey="Kelly L">LM Kelly</name></author><author><name sortKey="Heck, S" uniqKey="Heck S">S Heck</name></author><author><name sortKey="Graf, T" uniqKey="Graf T">T Graf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Jl" uniqKey="Li J">JL Li</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Berlin</li><li>District de Karlsruhe</li><li>District de Tübingen</li><li>Maryland</li><li>Rhénanie-Palatinat</li></region><settlement><li>Berlin</li><li>Heidelberg</li><li>Mayence</li><li>Tübingen</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Herster, Franziska" sort="Herster, Franziska" uniqKey="Herster F" first="Franziska" last="Herster">Franziska Herster</name></region><name sortKey="Bittner, Zsofia" sort="Bittner, Zsofia" uniqKey="Bittner Z" first="Zsofia" last="Bittner">Zsofia Bittner</name><name sortKey="Dickhofer, Sabine" sort="Dickhofer, Sabine" uniqKey="Dickhofer S" first="Sabine" last="Dickhöfer">Sabine Dickhöfer</name><name sortKey="Eigenbrod, Tatjana" sort="Eigenbrod, Tatjana" uniqKey="Eigenbrod T" first="Tatjana" last="Eigenbrod">Tatjana Eigenbrod</name><name sortKey="Eisel, David" sort="Eisel, David" uniqKey="Eisel D" first="David" last="Eisel">David Eisel</name><name sortKey="Eisel, David" sort="Eisel, David" uniqKey="Eisel D" first="David" last="Eisel">David Eisel</name><name sortKey="Freund, Lukas" sort="Freund, Lukas" uniqKey="Freund L" first="Lukas" last="Freund">Lukas Freund</name><name sortKey="Ghoreschi, Kamran" sort="Ghoreschi, Kamran" uniqKey="Ghoreschi K" first="Kamran" last="Ghoreschi">Kamran Ghoreschi</name><name sortKey="Ghoreschi, Kamran" sort="Ghoreschi, Kamran" uniqKey="Ghoreschi K" first="Kamran" last="Ghoreschi">Kamran Ghoreschi</name><name sortKey="Hartl, Dominik" sort="Hartl, Dominik" uniqKey="Hartl D" first="Dominik" last="Hartl">Dominik Hartl</name><name sortKey="Heine, Holger" sort="Heine, Holger" uniqKey="Heine H" first="Holger" last="Heine">Holger Heine</name><name sortKey="Heister, Martin" sort="Heister, Martin" uniqKey="Heister M" first="Martin" last="Heister">Martin Heister</name><name sortKey="Kalbacher, Hubert" sort="Kalbacher, Hubert" uniqKey="Kalbacher H" first="Hubert" last="Kalbacher">Hubert Kalbacher</name><name sortKey="Knorpp, Thomas" sort="Knorpp, Thomas" uniqKey="Knorpp T" first="Thomas" last="Knorpp">Thomas Knorpp</name><name sortKey="Loffler, Markus W" sort="Loffler, Markus W" uniqKey="Loffler M" first="Markus W." last="Löffler">Markus W. Löffler</name><name sortKey="Loffler, Markus W" sort="Loffler, Markus W" uniqKey="Loffler M" first="Markus W." last="Löffler">Markus W. Löffler</name><name sortKey="Loffler, Markus W" sort="Loffler, Markus W" uniqKey="Loffler M" first="Markus W." last="Löffler">Markus W. Löffler</name><name sortKey="Sch Kel, Knut" sort="Sch Kel, Knut" uniqKey="Sch Kel K" first="Knut" last="Sch Kel">Knut Sch Kel</name><name sortKey="Schneiderhan Marra, Nicole" sort="Schneiderhan Marra, Nicole" uniqKey="Schneiderhan Marra N" first="Nicole" last="Schneiderhan-Marra">Nicole Schneiderhan-Marra</name><name sortKey="Vierbuchen, Tim" sort="Vierbuchen, Tim" uniqKey="Vierbuchen T" first="Tim" last="Vierbuchen">Tim Vierbuchen</name><name sortKey="Weber, Alexander N R" sort="Weber, Alexander N R" uniqKey="Weber A" first="Alexander N. R." last="Weber">Alexander N. R. Weber</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Archer, Nathan K" sort="Archer, Nathan K" uniqKey="Archer N" first="Nathan K." last="Archer">Nathan K. Archer</name></region><name sortKey="Miller, Lloyd S" sort="Miller, Lloyd S" uniqKey="Miller L" first="Lloyd S." last="Miller">Lloyd S. Miller</name></country><country name="Suisse"><noRegion><name sortKey="Hartl, Dominik" sort="Hartl, Dominik" uniqKey="Hartl D" first="Dominik" last="Hartl">Dominik Hartl</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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